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KMID : 0043320100330020197
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Archives of Pharmacal Research
2010 Volume.33 No. 2 p.197 ~ p.202
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Design and Synthesis of 3’-Fluoropenciclovir Analogues as Antiviral Agents
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Kim Hee-Doo
Choi Myung-Hee
Lee Chong-Kyo
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Abstract
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Based on fluorine switch approach, a series of 3’-fluoropenciclovir analogues with different purine and pyrimidine bases were designed and synthesized. Direct reduction of β-fluoroester to the corresponding 3-fluoroalcohol provided an easy and new entry pathway towards the synthesis of 3’-fluoropenciclovir analogues. The synthesized 3’-fluoropenciclovir analogues were evaluated for their antiviral activities against the poliovirus, HSV-1, HSV-2 and HIV.
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KEYWORD
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Antiviral, Fluorine switch, Penciclovir, 3’-Fluoropenciclovir
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